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1

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

Lewis, Huw D, Liddle, John, Coote, Jim E, Atkinson, Stephen J, Barker, Michael D, Bax, Benjamin D, Bicker, Kevin L, Bingham, Ryan P, Campbell, Matthew, Chen, Yu Hua, Chung, Chun-wa, Craggs, Peter D, D

Journal:

Nature Chemical Biology

Year:

2015

Language:

english

File:

PDF, 1.08 MB

english, 2015

2

Fragments in bromodomain drug discovery

Bamborough, Paul, Chung, Chun-wa

Journal:

Year:

2015

Language:

english

File:

PDF, 4.35 MB

english, 2015

3

A Chemical Probe for the ATAD2 Bromodomain

Bamborough, Paul, Chung, Chun-wa, Demont, Emmanuel H., Furze, Rebecca C., Bannister, Andrew J., Che, Ka Hing, Diallo, Hawa, Douault, Clement, Grandi, Paola, Kouzarides, Tony, Michon, Anne-Marie, Mitch

Journal:

Angewandte Chemie International Edition

Year:

2016

Language:

english

File:

PDF, 1.45 MB

english, 2016

4

Integration of Lead Discovery Tactics and the Evolution of the Lead Discovery Toolbox

Leveridge, Melanie, Chung, Chun-Wa, Gross, Jeffrey W., Phelps, Christopher B., Green, Darren

Journal:

Year:

2018

Language:

english

File:

PDF, 1.62 MB

english, 2018

5

Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome

Schulz, Danae, Mugnier, Monica R., Paulsen, Eda-Margaret, Kim, Hee-Sook, Chung, Chun-wa W., Tough, David F., Rioja, Inmaculada, Prinjha, Rab K., Papavasiliou, F. Nina, Debler, Erik W., Carruthers, Ver

Journal:

Year:

2015

Language:

english

File:

PDF, 6.35 MB

english, 2015

6

Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3-Kinase Î´

Spencer, Jonathan A., Baldwin, Ian R, Barton, Nick, Chung, Chun-Wa, Convery, Maire A., Edwards, Christopher D., Jamieson, Craig, Mallett, David N., Rowedder, James E., Rowland, Paul, Thomas, Daniel A,

Journal:

ACS Medicinal Chemistry Letters

Year:

2020

File:

PDF, 423 KB

2020

7

“FLIPSY”—A New Solvent-Suppression Sequence for Nonexchanging Solutes Offering Improved Integral Accuracy Relative to 1D NOESY

David Neuhaus, Ismail M. Ismail, Chun-Wa Chung

Journal:

Journal of Magnetic Resonance, Series A

Year:

1996

Language:

english

File:

PDF, 173 KB

english, 1996

8

Three- and five-quantum filtration experiments in 25Mg NMR of a macromolecular system

Chun-wa Chung, Stephen Wimperis

Journal:

Chemical Physics Letters

Year:

1990

Language:

english

File:

PDF, 409 KB

english, 1990

9

Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes

Richard M. Angell, Tony D. Angell, Paul Bamborough, Mark J. Bamford, Chun-wa Chung, Stuart G. Cockerill, Stephen S. Flack, Katherine L. Jones, Dramane I. Laine, Timothy Longstaff, Steve Ludbrook, Rosa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 609 KB

english, 2008

10

Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with biaryl P4 motifs

Robert J. Young, Alan D. Borthwick, David Brown, Cynthia L. Burns-Kurtis, Matthew Campbell, Chuen Chan, Marie Charbaut, Chun-wa Chung, Máire A. Convery, Henry A. Kelly, N. Paul King, Savvas Kleanthous

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 238 KB

english, 2008

11

Conformational Analysis of Neuropeptide Y Segments by CD, NMR Spectroscopy and Restrained Molecular Dynamics

Marion Gurrath, Alessandro Bisello, Katia Bottazzo, Chun-Wa Chung, Stefano Mammi, Evaristo Peggion

Journal:

Journal of Peptide Science

Year:

1996

Language:

english

File:

PDF, 1.23 MB

english, 1996

12

Optimum detection of spin-32 biexponential relaxation using multiple-quantum filtration techniques

Chun-Wa Chung, Stephen Wimperis

Journal:

Journal of Magnetic Resonance (1969)

Year:

1969

Language:

english

File:

PDF, 524 KB

english, 1969

13

Suppression of inflammation by a synthetic histone mimic

Chung, Chun-wa, Chandwani, Rohit, Marazzi, Ivan, Wilson, Paul, Coste, Hervé, Nicodeme, Edwige, Jeffrey, Kate L., Schaefer, Uwe, Beinke, Soren, Dewell, Scott

Journal:

Year:

2010

Language:

english

File:

PDF, 964 KB

english, 2010

14

Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery

Chung, Chun-wa, Dean, Anthony W., Woolven, James M., Bamborough, Paul

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 5.37 MB

english, 2012

15

Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides

Bamborough, Paul, Diallo, Hawa, Goodacre, Jonathan D., Gordon, Laurie, Lewis, Antonia, Seal, Jonathan T., Wilson, David M., Woodrow, Michael D., Chung, Chun-wa

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 773 KB

english, 2012

16

Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains

Chung, Chun-wa, Coste, Hervé, White, Julia H., Mirguet, Olivier, Wilde, Jonathan, Gosmini, Romain L., Delves, Chris, Magny, Sylvie M., Woodward, Robert, Hughes, Stephen A.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 4.89 MB

english, 2011

17

Measurement of spin-5/2 relaxation in biological and macromolecular systems using multiple-quantum NMR techniques

Chung, Chun-Wa, Wimperis, Stephen

Journal:

Molecular Physics

Year:

1992

Language:

english

File:

PDF, 1.70 MB

english, 1992

18

Selectivity of Kinase Inhibitor Fragments

Bamborough, Paul, Brown, Murray J., Christopher, John A., Chung, Chun-wa, Mellor, Geoff W.

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.16 MB

english, 2011

19

Crystallographic analysis reveals the structural basis of the high-affinity binding of iophenoxic acid to human serum albumin

Ali J Ryan, Chun-wa Chung, Stephen Curry

Journal:

BMC Structural Biology

Year:

2011

Language:

english

File:

PDF, 1.86 MB

english, 2011

20

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

Kruidenier, Laurens, Chung, Chun-wa, Cheng, Zhongjun, Liddle, John, Che, KaHing, Joberty, Gerard, Bantscheff, Marcus, Bountra, Chas, Bridges, Angela, Diallo, Hawa, Eberhard, Dirk, Hutchinson, Sue, Jon

Journal:

Year:

2012

Language:

english

File:

PDF, 1.17 MB

english, 2012

21

4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy

John Liddle, Paul Bamborough, Michael D. Barker, Sebastien Campos, Chun-Wa Chung, Rick P.C. Cousins, Paul Faulder, Michelle L. Heathcote, Heather Hobbs, Duncan S. Holmes, Chris Ioannou, Cesar Ramirez-

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.04 MB

english, 2012

22

Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin

Ali J. Ryan, Jamie Ghuman, Patricia A. Zunszain, Chun-wa Chung, Stephen Curry

Journal:

Journal of Structural Biology

Year:

2011

Language:

english

File:

PDF, 1.32 MB

english, 2011

23

Bromodomains: a new target class for small molecule drug discovery

Chun-wa Chung, David F. Tough

Journal:

Drug Discovery Today: Therapeutic Strategies

Year:

2012

Language:

english

File:

PDF, 989 KB

english, 2012

24

The Molecular Basis of Selectivity Between CC and CXC Chemokines: The Possibility of Chemokine Antagonists as Anti-inflammatory Agents

TIMOTHY N. C. WELLS, MANJULA LUSTI-NARASIMHAN, CHUN-WA CHUNG, ROBERT COOKE, CHRISTINE A. POWER, MANUEL C. PEITSCH, AMANDA E. I. PROUDFOOT

Journal:

Annals of the New York Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.33 MB

english, 1996

25

Effect of Detergent on “Promiscuous” Inhibitors

Ryan, Ali J., Gray, Norman M., Lowe, Peter N., Chung, Chun-wa

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 183 KB

english, 2003

26

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Dawson, Mark A., Prinjha, Rab K., Dittmann, Antje, Giotopoulos, George, Bantscheff, Marcus, Chan, Wai-In, Robson, Samuel C., Chung, Chun-wa, Hopf, Carsten, Savitski, Mikhail M., Huthmacher, Carola, Gu

Journal:

Year:

2011

Language:

english

File:

PDF, 2.14 MB

english, 2011

27

[Progress in Medicinal Chemistry] Progress in Medicinal Chemistry Volume 51 Volume 51 || Small Molecule Bromodomain Inhibitors

Year:

2012

Language:

english

File:

PDF, 2.86 MB

english, 2012

28

Identification of a Glycosaminoglycan Binding Surface on Human Interleukin-8

Kuschert, Gabriele S. V., Hoogewerf, Arlene J., Proudfoot, Amanda E. I., Chung, Chun-wa, Cooke, Robert M., Hubbard, Roderick E., Wells, Timothy N. C., Sanderson, Paul N.

Journal:

Year:

1998

Language:

english

File:

PDF, 136 KB

english, 1998

29

Factor Xa Inhibitors: S1 Binding Interactions of a Series of N -{( 3S )-1-[( 1S )-1-Methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides †

Chan, Chuen, Borthwick, Alan D., Brown, David, Burns-Kurtis, Cynthia L., Campbell, Matthew, Chaudry, Laiq, Chung, Chun-wa, Convery, Máire A., Hamblin, J. Nicole, Johnstone, Lisa, Kelly, Henry A., Klea

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 454 KB

english, 2007

30

Naphthyridines as Novel BET Family Bromodomain Inhibitors

Mirguet, Olivier, Lamotte, Yann, Chung, Chun-wa, Bamborough, Paul, Delannée, Delphine, Bouillot, Anne, Gellibert, Françoise, Krysa, Gael, Lewis, Antonia, Witherington, Jason, Huet, Pascal, Dudit, Yann

Journal:

Year:

2014

Language:

english

File:

PDF, 996 KB

english, 2014

31

The structure based design of dual HDAC/BET inhibitors as novel epigenetic probes

Atkinson, Stephen J., Soden, Peter E., Angell, Davina C., Bantscheff, Marcus, Chung, Chun-wa, Giblin, Kathryn A., Smithers, Nicholas, Furze, Rebecca C., Gordon, Laurie, Drewes, Gerard, Rioja, Inmacula

Journal:

Year:

2014

Language:

english

File:

PDF, 1.11 MB

english, 2014

32

The Commonly Used PI3-Kinase Probe LY294002 Is an Inhibitor of BET Bromodomains

Dittmann, Antje, Werner, Thilo, Chung, Chun-Wa, Savitski, Mikhail M., Fälth Savitski, Maria, Grandi, Paola, Hopf, Carsten, Lindon, Matthew, Neubauer, Gitte, Prinjha, Rabinder K., Bantscheff, Marcus, D

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 2.18 MB

english, 2014

33

Magnesium Fluoride-Dependent Binding of Small G Proteins to Their GTPase-Activating Proteins †

Graham, Debbie L., Eccleston, John F., Chung, Chun-Wa, Lowe, Peter N.

Journal:

Year:

1999

Language:

english

File:

PDF, 79 KB

english, 1999

34

The Three-Dimensional Solution Structure of RANTES

Chung, Chun-wa, Cooke, Robert M., Proudfoot, Amanda E. I., Wells, Timothy N. C.

Journal:

Year:

1995

Language:

english

File:

PDF, 2.97 MB

english, 1995

35

1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain

Demont, Emmanuel H., Bamborough, Paul, Chung, Chun-wa, Craggs, Peter D., Fallon, David, Gordon, Laurie J., Grandi, Paola, Hobbs, Clare I., Hussain, Jameed, Jones, Emma J., Le Gall, Armelle, Michon, An

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 410 KB

english, 2014

36

Kruidenier et al. reply

Kruidenier, Laurens, Chung, Chun-wa, Cheng, Zhongjun, Liddle, John, Che, KaHing, Joberty, Gerard, Bantscheff, Marcus, Bountra, Chas, Bridges, Angela, Diallo, Hawa, Eberhard, Dirk, Hutchinson, Sue, Jon

Journal:

Year:

2014

Language:

english

File:

PDF, 158 KB

english, 2014

37

Design of histidine-Zn2+ binding sites within a β-hairpin peptide: enhancement of β-sheet stability through metal complexation

Platt, Geoffrey, Searle, Mark S., Chung, Chun-Wa

Journal:

Chemical Communications

Year:

2001

Language:

english

File:

PDF, 139 KB

english, 2001

38

Human Macrophage Migration Inhibitory Factor

Kudrin, Alex, Scott, Martin, Martin, Steven, Chung, Chun-wa, Donn, Rachelle, McMaster, Andrew, Ellison, Stuart, Ray, David, Ray, Keith, Binks, Michael

Journal:

Journal of Biological Chemistry

Year:

2006

Language:

english

File:

PDF, 1.09 MB

english, 2006

39

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B

Chen, Peiling, Chaikuad, Apirat, Bamborough, Paul, Bantscheff, Marcus, Bountra, Chas, Chung, Chun-wa, Fedorov, Oleg, Grandi, Paola, Jung, David, Lesniak, Robert, Lindon, Matthew, Müller, Susanne, Phil

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 7.19 MB

english, 2015

40

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

Theodoulou, Natalie H., Bamborough, Paul, Bannister, Andrew J., Becher, Isabelle, Bit, Rino A., Che, Ka Hing, Chung, Chun-wa, Dittmann, Antje, Drewes, Gerard, Drewry, David H., Gordon, Laurie, Grandi,

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 6.90 MB

english, 2015

41

The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits

Bertrand, Sophie M., Ancellin, Nicolas, Beaufils, Benjamin, Bingham, Ryan P., Borthwick, Jennifer A., Boullay, Anne-Bénédicte, Boursier, Eric, Carter, Paul S., Chung, Chun-wa, Churcher, Ian, Dodic, Ne

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 5.39 MB

english, 2015

42

Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors

Demont, Emmanuel H., Chung, Chun-wa, Furze, Rebecca C., Grandi, Paola, Michon, Anne-Marie, Wellaway, Chris, Barrett, Nathalie, Bridges, Angela M., Craggs, Peter D., Diallo, Hawa, Dixon, David P., Doua

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 7.16 MB

english, 2015

43

Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors

Bamborough, Paul, Chung, Chun-wa, Furze, Rebecca C., Grandi, Paola, Michon, Anne-Marie, Sheppard, Robert J., Barnett, Heather, Diallo, Hawa, Dixon, David P., Douault, Clement, Jones, Emma J., Karamshi

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 6.46 MB

english, 2015

44

Novel interaction mechanism of a domain antibody based inhibitor of human vascular endothelial growth factor with greater potency than ranibizumab and bevacizumab and improved capacity over aflibercept.

Walker, Adam, Chung, Chun-wa, Neu, Margaret, Burman, Manish, Batuwangala, Thil, Jones, Gavin, Tang, Chi-Man, Steward, Michael, Mullin, Michael, Tournier, Nadia, Lewis, Alan, Korczynska, Justyna, Chung

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 2.09 MB

english, 2016

45

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives

Westaway, Susan M., Preston, Alex G. S., Barker, Michael D., Brown, Fiona, Brown, Jack A., Campbell, Matthew, Chung, Chun-wa, Diallo, Hawa, Douault, Clement, Drewes, Gerard, Eagle, Robert, Gordon, Lau

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 3.58 MB

english, 2016

46

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4- d ]pyrimidin-4(3 H )-one Derivatives

Westaway, Susan M., Preston, Alex G. S., Barker, Michael D., Brown, Fiona, Brown, Jack A., Campbell, Matthew, Chung, Chun-wa, Drewes, Gerard, Eagle, Robert, Garton, Neil, Gordon, Laurie, Haslam, Carl,

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 2.59 MB

english, 2016

47

New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold

Pajk, Stane, Živec, Matej, Šink, Roman, Sosič, Izidor, Neu, Margarete, Chung, Chun-wa, Martínez-Hoyos, María, Pérez-Herrán, Esther, Álvarez-Gómez, Daniel, Álvarez-Ruíz, Emilio, Mendoza-Losana, Alfonso

Journal:

European Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 666 KB

english, 2016

48

Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads With Varying Binding Modes Identified by Fragment Screening

Borthwick, Jennifer A, Ancellin, Nicolas, Bertrand, Sophie Marie, Bingham, Ryan P, Carter, Paul S, Chung, Chun-Wa, Churcher, Ian, Dodic, Nerina, Fournier, Charlene, Francis, Peter L, Hobbs, Andrew, Ja

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.75 MB

english, 2016

49

GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain

Bamborough, Paul, Barnett, Heather A., Becher, Isabelle, Bird, Mark J., Chung, Chun-wa, Craggs, Peter D., Demont, Emmanuel H., Diallo, Hawa, Fallon, David J., Gordon, Laurie J., Grandi, Paola, Hobbs,

Journal:

ACS Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 2.52 MB

english, 2016

50

Biophysics in drug discovery: impact, challenges and opportunities

Renaud, Jean-Paul, Chung, Chun-wa, Danielson, U. Helena, Egner, Ursula, Hennig, Michael, Hubbard, Roderick E., Nar, Herbert

Journal:

Nature Reviews Drug Discovery

Year:

2016

Language:

english

File:

PDF, 739 KB

english, 2016